There are enough concerns about Newton to at least put doubt in your mind and this is a pick you simply cannot afford to miss on.
If the Panthers have done all their research on Newton, and clearly they will have done, and still feel confident about him then all power to them. But based on the little information that is available to the general public there seems to be some major warning signs.
One year of production
Numerous documented off the field issues(not including whatever his father may or may not have done)
Is he truly devoted to football or being an "entertainer and an icon"
He will be coming from a zone read option offense to a pro style offense
One of those issues is worrying enough for the team drafting 1st overall, however all of them combined are huge.